Current Research Interests
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Epigenetics
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Discover isoform-specific KDAC inhibitors for therapeutic use in:
malaria and schistosomiasis : by optimizing the affinity and species specificity of Plasmodium and S. mansoni lysine deacetylases (pfKDAC1 and smKDAC8, respectively)
AIDS and oncology: by discovering isoform-specific KDAC inhibitors to eradicate HIV-1 latency
- Develop predictive quantitative models to find and design compounds with optimal drug-like properties
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Targeting dimerization of ErbB tyrosine kinase transmembrane receptors
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- Discover inhibitors of each type of hetero- and homodimerization of ErbB/HER receptors and their oncogenic mutants
- Develop predictive quantitative models to find and design compounds with optimal drug-like properties
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