Welcome

Welcome to the Garland R. Marshall’s research group website. Our laboratories are in the Biochemistry and Molecular Biophysics Department at the Washington University School of Medicine in St. Louis. Our major focus is molecular recognition – the basis of intermolecular interactions and specificity seen in drug and hormone receptors, antigen-antibody and substrate-enzyme systems.

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          Current Research Interests

          Epigenetics
          • Discover isoform-specific KDAC inhibitors for therapeutic use in:

            malaria and schistosomiasis : by optimizing the affinity and species specificity of Plasmodium and S. mansoni  lysine deacetylases (pfKDAC1 and smKDAC8, respectively)

            AIDS and oncology: by discovering isoform-specific KDAC inhibitors to eradicate HIV-1 latency

          • Develop predictive quantitative models to find and design compounds with optimal drug-like properties
          Targeting dimerization of ErbB tyrosine kinase transmembrane receptors
          • Discover inhibitors of each type of hetero- and homodimerization of ErbB/HER receptors and their oncogenic mutants
          • Develop predictive quantitative models to find and design compounds with optimal drug-like properties